Heya,
I came across this Forum, have a look and see, there is also seems to be a problem with EAX support that crashes the game, but then it will give you a error lock.... So there seems to me more then one cuase for crashing.
Check this hxxp://www.techimo.com/forum/t36734.html link to see for more help!
Cheers

Jaco
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Ok I got the game to work, I used a no cd crack on this page h..p://66.227.103.236/pcgamefixes/HITMAN.2.SILENT.ASSASSIN.V10.ENG.GIMPSRUS.NOCD.ZIP , I aslo have a EAXDisable in the hitman2.ini file, but that might not be needed by all to get the game working...
Good Luck!!
Jaco