While it might work, I would discourage it. AV programs are very effective at reducing the speed of disk access. Every file that is to be read or written needs to be scanned and have it's signature checked against thousands of known viruses.
I find that using NAV, there is a noticalbe lag when opening large files. F-Prot is better, but it still makes a noticable performance decrease.
I personally try avoid running AV programs all together for the above reasons. I'm careful enough not to run executable files from untrusted sources, and I run whatever I can using the "run as..." command, and selecting a user account with limited access. In cases where I download a file I'm not sure about, I manually scan it, rather than having real-time protection running non-stop. 99.999% of virus infections nowadays are due to novice users thinking it's a good idea to open "brittney nude!! (Real!11!).jpg.mpg.vbs.com.exe" email attachments.
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