well....first off, if you plan on hosting over the internet, you need a static ip. if you dont have one, you can use something like no-ip or dns2go (but you have to pay for that one now) to simulate having a static ip.
this is my own personal way of doing it, but i know that a lot of people have different methods that work well for them.
i use windows 2000 server with IIS to run ftp. lots of members here use a third party tool such as bulletproof or servU as their ftp servers and they seem to work just as well. i make sure all my permissions are strong and all my users are set up correctly.
basically, make sure you have a static IP or something like it, you have a good program to serve with (IIS or a third party program) and that you're secure. going into windows 2000 permissions and groups is a whole tutorial on its own...
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