There is a fascinating article in the latest edition of a free magazine I subscribe to at
http://windowssecrets.com. It reports on a major comparison study of the effectiveness of adware removal software. As example, while Giant Antispyware fixed 63% with no false positives, Pest Patrol fixed only 41% with 10 false positives. Even more interesting is the effect of combination which reports that the popular combination of Adaware and Spybot caught only 54%.
It's worth reading.