I run NOD32 and Zone Alarm Pro and I am locked up pretty well...never had a problem yet. Used to run McAfee and ZA Pro but McAfee gets in the way and is a comparitive resource hog to NOD32. For free you can go with AVG Antivirus and Zone Alarm (free version) and you should be pretty good...I would go this way if you are on a real tight budget.
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